Invasive fungal infections in children with rheumatic diseases
نویسندگان
چکیده
منابع مشابه
Invasive fungal infections in children.
The past two decades have seen a considerable increase in both frequency and importance of opportunistic invasive fungal infections in pediatric hospitals. At the same time, major advances have been made in the diagnosis of fungal diseases, the development of algorithms of antifungal interventions, and the design and implementation of pediatric clinical trials. Most importantly, several new ant...
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OBJECTIVE Fungal infection is a significant problem, causing of infective deaths of leukemic patients. The situation in developing countries is not well documented. The purpose of this study was characterizing IFD by analyzing data retrospectively to determine the incidence, predisposing factors, diagnostic methods, efficacy of treatment, and the outcome in pediatric patients with hematological...
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Results Thrombotic events have been associated with antiphospholipid antibodies in autoimmune diseases, including systemic lupus erythematosus (SLE). However, pulmonary thromboembolism (PTE) from deep vein thromboses (DVT) or in situ pulmonary arterial thrombosis is uncommon in rheumatic diseases, especially in children. The diagnosis and treatment of PTE may be delayed due to a paucity of symp...
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Voriconazole, a second-generation and broad-spectrum triazole derivative of fluconazole, inhibits the cytochrome P450 (CYP)-dependent enzyme 14-α-sterol demethylase, which is a pivotal step in cell membrane ergosterol synthesis in fungi. CYP2C19, CYP3A4, flavin-containing monooxygenase (FMO), and to a lesser extent CYP2C9 contribute to the oxidative metabolism of voriconazole by human liver mic...
متن کاملGlucocorticoids and invasive fungal infections.
Since the 1990s, opportunistic fungal infections have emerged as a substantial cause of morbidity and mortality in profoundly immunocompromised patients. Hypercortisolaemic patients, both those with endogenous Cushing's syndrome and, much more frequently, those receiving exogenous glucocorticoid therapy, are especially at risk of such infections. This vulnerability is attributed to the complex ...
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ژورنال
عنوان ژورنال: Journal Infectology
سال: 2021
ISSN: 2072-6732
DOI: 10.22625/2072-6732-2020-12-5-48-55